About

About PhosphoLink

PhosphoLink is a literature-scale resource for phosphorylation and dephosphorylation regulation. Large-scale systematic literature screening yielded supporting records for curated regulatory relationships. Each relationship is linked to site-specific, sentence-level evidence, with isoform-aware site mapping and interactive network exploration.

PhosphoLink also integrates site-specific kinase–substrate and phosphatase–substrate relationships from curated external resources, and enriches entries using public databases and open-source software. See Acknowledgements for the full list.

For questions about PhosphoLink data, methods, website feedback, or collaboration, please contact:

Yichuan Zhang (yichuan@usf.edu)

Duolin Wang (duolinwang@usf.edu)

License

PhosphoLink curated database exports and website content created by the PhosphoLink team are licensed under Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0).

You may share and adapt this material for non-commercial purposes provided you give appropriate credit, indicate if changes were made, and distribute derivatives under the same license. Third-party data integrated into PhosphoLink remain subject to their original terms and licenses.

For commercial use, please contact:

Duolin Wang (duolinwang@usf.edu)

Acknowledgements

PhosphoLink builds on public databases and open-source software. We thank the communities behind these resources. Each database remains subject to its own terms and licenses.

Integrated regulatory resources

Regulatory relationship evidence integrated into PhosphoLink comes from:

These resources integrate data from upstream databases including KEA, HPRD, SIGNOR, dbPTM, phosphoELM, PGRD, neXtProt, RLIMS-P, and PhosphoSitePlus.

Reference data for protein and literature entries

  • UniProt — protein names, gene symbols, function, and sequences
  • AlphaFold DB — predicted protein structures displayed on protein entries
  • PubMed — source literature metadata and publication links

Open-source software

  • Cytoscape.js — interactive regulatory network visualization
  • 3Dmol.js — 3D protein structure viewer on protein entries